Conference attendees listen to a scientific session at the 2025 American Physiology Summit. Originally developed to treat diabetes, glucagon-like peptide-1 (GLP-1) agonists have recently dominated media coverage due to their potent effects on weight loss. Preliminary research has also suggested that these drugs may also have a protective role in other body systems and improve … Continue reading GLP-1 Agonists: More Than Just Weight Loss
Obesity
GLP-1 Drugs for Weight Loss: From Science Fiction to Reality
Credit: iStock/zimmytws Obesity affects more than one billion people around the world. Historically, the genetic ability to store body fat is an evolutionary conserved adaptation to stave off starvation. The combination of the superb ability to store body fat, a high rate of sedentary lifestyle and an abundance of ultra-processed foods—a food landscape our great-grandparents … Continue reading GLP-1 Drugs for Weight Loss: From Science Fiction to Reality
Can Intermittent Fasting Prevent Kidney Damage in Obesity?
Claudia Edell presents her research at the American Physiology Summit. Credit: Claudia Edell Obesity is extremely prevalent in the U.S. population and can lead to a variety of health complications, such as high blood pressure, endothelial dysfunction, inflammation and even chronic kidney disease. Intermittent fasting—referred to as “time-restricted feeding” in research—is a popular diet in … Continue reading Can Intermittent Fasting Prevent Kidney Damage in Obesity?
Spotlight On: Obesity
Credit: iStock Obesity, broadly defined as “a condition characterized by the excessive accumulation and storage of fat in the body,” has long been recognized as increasing the risk of human disease and death. Hippocrates, often called the “father of medicine,” noted in the fifth century B.C. that “sudden death is more common in those who … Continue reading Spotlight On: Obesity
The COVID ‘15’: Staying Healthy and Informed during a Pandemic
Credit: iStock When the world came to an abrupt halt in early 2020 as the COVID-19 pandemic took hold, some people who had been keeping up with a healthy lifestyle, including proper nutrition and exercise, slid out of these habits. This happened for a variety of reasons, such as lack of access to exercise equipment, … Continue reading The COVID ‘15’: Staying Healthy and Informed during a Pandemic
Bariatric Surgery Reveals Complexities of Our Hunger Systems
Bariatric surgery affects a variety of physiological processes in the human body, including brain signaling, hormones, blood composition and the microbiome.
2020’s Most-read I Spy Physiology Posts
Credit: iStock In a year like no other in our lifetimes, many of us found ourselves putting aside our usual pursuits and thirsting for information on the coronavirus pandemic. I Spy Physiology blog contributors quickly switched gears to keep you informed, including a series of posts covering the physiology of COVID-19 and how it affects … Continue reading 2020’s Most-read I Spy Physiology Posts
Giving Sugar the Run-around: How Exercise Protects Blood Vessels from Sugary Drinks
Credit: iStock An estimated 70% of people living in the U.S. add too much sugar, about 23 teaspoons, to their diet each day. This is alarming because diets high in added sugar increase the risk for developing chronic conditions such as obesity, type 2 diabetes and heart disease, which is the leading cause of death … Continue reading Giving Sugar the Run-around: How Exercise Protects Blood Vessels from Sugary Drinks
Is Dropping Junk Food the Key to Weight Loss?
Credit: iStock Since 1975, obesity has nearly tripled, now affecting over 650 million adults worldwide. Scientists know that diet can influence obesity—researchers have thought that ultra-processed or “junk” foods are part of the cause—but until recently, there have not been many studies to support the claim. Ultra-processed foods such as soda, pre-packaged items, cold cuts … Continue reading Is Dropping Junk Food the Key to Weight Loss?
The Surprising Health Benefits of ‘Yo-yo’ Dieting
Credit: iStock It’s not really news that obesity and the trend of increasing waistlines seems to only be heading upward—and outward. Despite efforts to fight the fat, many people end up regaining the weight they lose when they diet in a phenomenon known as “weight cycling” or “yo-yo dieting.” Weight cycling can be frustrating, and … Continue reading The Surprising Health Benefits of ‘Yo-yo’ Dieting